Vardenafil hydrochloride trihydrate（b） ( BAY 38-9456;Vardenafil HCl; Levitra; Staxyn; Vivanza )

产品货号. M18429 CAS No. 330808-88-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Vardenafil hydrochloride trihydrate（b）
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
产品描述

Vardenafil, also known as BAY 38-9456, is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil (VAR) is synthetic, highly selective, and potent inhibitor of phosphodiesterase-5 which competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. It is clinically approved for treatment of erectile dysfunction in men, including diabetic and postprostatectomy patients.
同义词

BAY 38-9456;Vardenafil HCl; Levitra; Staxyn; Vivanza
通路

Others
靶点

Other Targets
受体

PDE1; PDE5
研究领域

Cardiovascular Disease
适应症

——

CAS Number

330808-88-3
分子量

579.11
分子式

C23H32N6O4S·HCl·3H2O
纯度

98%
溶解度

——
SMILES

n12[nH]c(nc(=O)c1c(nc2CCC)C)c1c(ccc(c1)S(=O)(=O)N1CCN(CC1)CC)OCC.Cl.O.O.O
化学全称

2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one dihydrochloride trihydrate

1 Saenz de Tejada I, et al. Int J Impot Res, 2001, 13(5), 282-290.

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